Bioinformatics Profiling of a Paeoniflorin-Associated "Macrophage-Lactylation" Axis in Hepatocellular Carcinoma: An LDHA-Based Prognostic Model and Structural Computational Evidence - PubMed
2 months ago
- #lactylation
- #prognostic model
- #hepatocellular carcinoma
- 研究聚焦于肝细胞癌（HCC）中巨噬细胞-乳酸化分子轴的作用
- 利用HNRNPU、LDHA和NPM1基因构建了预后预测模型
- 高风险患者总体生存期更差（p < 0.001）
- 分子对接显示芍药苷（PF）与LDHA存在强结合力
- 该模型通过计算证据将芍药苷与LDHA等关键分子节点相关联