PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment - PubMed
2 months ago
- #immunotherapy
- #glioblastoma
- #PAK4
- PAK4通过改变CD8+ T细胞代谢在胶质母细胞瘤中发挥免疫抑制作用
- PAK4促进TGF-β1释放，激活CD8+ T细胞中PI3K/AKT/NF-κB通路，导致PLA2G4A上调
- PLA2G4A引起磷脂酰胆碱耗竭，损害CD8+ T细胞的线粒体和溶酶体功能
- 抑制PLA2G4A可减轻CD8+ T细胞耗竭并增强其细胞毒性能力
- PAK4抑制剂联合抗PD-L1疗法可改善CD8+ T细胞功能并抑制肿瘤生长