Hippocampal Hap1 downregulation exacerbates Alzheimer's disease-related neuropathology through impairment of glucocorticoid receptor nuclear translocation in APP/PS1 mice - PubMed
2 months ago
- #Alzheimer's disease
- #Glucocorticoid receptor
- #Synaptic plasticity
- 海马组织中Hap1蛋白下调会加剧APP/PS1小鼠的阿尔茨海默病(AD)神经病理学改变
- Hap1调控糖皮质激素受体(GR)在海马中的核转位
- APP/PS1小鼠中Hap1表达随衰老和AD进展而降低
- Hap1敲除导致认知缺陷、突触丢失及β淀粉样蛋白沉积增加
- Hap1缺失会破坏GR核转位和脑源性神经营养因子(BDNF)转录
- Hap1敲除使皮质酮水平升高并引发抑郁样行为
- Hap1介导的GR核转位是AD突触功能障碍的关键机制
- 研究建议将Hap1调控作为AD潜在治疗靶点