The CureVac Vaccine, and a brief tour through some of the wonders of nature - Bert Hubert's writings
a day ago
- CureVac's vaccine uses unmodified mRNA, unlike BioNTech/Moderna which use modified nucleosides to evade immune detection.
- CureVac employs alternative strategies: a minimal 5' UTR with technical artifacts, a poly(C) stretch for stability, and a histone stem-loop for longevity.
- The vaccine's mRNA has high GC content (63%) and extensive codon modifications to enhance stability and protein expression.
- Unmodified mRNA may act as an adjuvant, potentially boosting immune response, but early trial results (June 16 update) were disappointing.
- The vaccine is designed for refrigerator stability, maintaining efficacy at regular temperatures.