New formulation helps RNA vaccines withstand high temperatures
4 hours ago
- Researchers at MIT have developed an AI-driven method to create heat-resistant RNA vaccines by optimizing lipid nanoparticle formulations.
- These stabilized vaccines can remain effective for up to a year at room temperature or two months at nearly 100°F, overcoming ultracold storage limitations.
- Using an AI algorithm that works with small datasets, the team reduced experiments and rapidly identified optimal excipient ratios, achieving stable vaccines that generate strong immune responses in mice.
- The approach allows for broader distribution of mRNA vaccines and supports novel delivery methods like microneedle patches, with potential applications beyond COVID-19, including cancer treatments.