A Science Experiment: part 1 - Bert Hubert's writings
a day ago
- The author describes the emotional rollercoaster of potentially discovering something new in biology, including fear of being wrong or scooped.
- DNA replication is a directional process, leading to Okazaki fragments on the lagging strand, which causes asymmetric mutation rates.
- This asymmetry results in GC skew—a measurable excess of G over C on one half of bacterial chromosomes—visible as strikingly straight lines across thousands of genomes.
- The author is analyzing ~23,000 bacterial chromosomes to uncover patterns in GC skew, with plans to share findings in part 2 of the series.