Reverse Engineering Source Code of the Biontech Pfizer Vaccine: Part 2 - Bert Hubert's writings
a day ago
- The vaccine mRNA has been optimized by changing specific RNA codons (e.g., UUU to UUC) to increase G and C content for improved efficiency.
- A leaderboard tracks algorithms that attempt to reverse-engineer the optimization, with current best achieving ~79.5% codon match using static mapping.
- The challenge is to design an algorithm that transforms wild-type viral RNA into the BNT162b2 vaccine RNA without peeking at the vaccine sequence.
- Factors influencing optimization include GC ratio management, codon frequency in human cells, and RNA folding for stability and immune evasion.
- The algorithm should only use original virus RNA as input, and participants can submit their code for inclusion in the leaderboard.