Functional Ultrasound Imaging from Scratch
5 hours ago
- Functional ultrasound imaging (fUSI) captures brain activity by measuring blood flow changes from neural activity, offering higher resolution, portability, and lower cost than fMRI.
- fUSI uses ultrafast plane wave transmission and delay-and-sum beamforming to reconstruct images, with resolution proportional to ultrasound wavelength.
- Power Doppler (PD) estimation tracks blood volume via standard deviation of speckle changes, but is sensitive to motion; clutter filtering via SVD removes >99% of variance.
- Advanced analysis includes autocorrelation for blood flow velocity, GLMs for task-related activation, and decoding models for movement intent, with resolution limited by vascular topology.
- Open-source Python tutorials on GitHub enable computational study of fUSI, covering propagation, structural/functional reconstruction, and real data analysis.