Ingeniería inversa del código fuente de la vacuna de BioNTech/Pfizer para el SARS-CoV-2 - Bert Hubert's writings
a day ago
- The article explains the mRNA vaccine's digital source code, consisting of 4284 characters that are translated into RNA molecules.
- Key components include a CAP, 5' untranslated region (UTR), optimized signal peptide, codon-optimized spike protein with two proline substitutions, 3' UTR, and a poly-A tail with a mysterious linker.
- Modifications like replacing U with 1-methyl-3'-pseudouridine (Ψ) evade the immune system, while codon optimization adds G and C for stability and higher protein expression.
- The two proline substitutions stabilize the spike protein in its prefusion conformation, crucial for effective immune response.
- The vaccine trains the immune system by having cells produce SARS-CoV-2 spike proteins without causing disease.
- Analogies between computer code and genetic code are drawn throughout, highlighting similarities in processing and optimization.