a day ago
- The mRNA vaccine code consists of 4284 characters, starting with 'GA' as a cap for legitimacy.
- RNA is fragile and requires ultra-low temperature storage, similar to RAM in computers.
- The vaccine uses 1-methyl-3'-pseudouridine (Ψ) instead of uracil to evade the immune system.
- The 5' untranslated region (UTR) provides a ribosome landing zone and is optimized for high protein expression.
- A signal peptide derived from the virus directs the spike protein to the endoplasmic reticulum.
- Codon optimization increases G and C content to enhance translation efficiency without changing amino acids.
- Two proline substitutions (K→P and V→P) stabilize the spike protein in its pre-fusion conformation, essential for immune response.
- The 3' UTR and poly-A tail (with a mysterious linker) improve mRNA stability and protein expression.
- The vaccine teaches the immune system to recognize the SARS-CoV-2 spike protein without causing disease.