Bilingual

Dekonstruktion des Programmcodes des BioNTech/Pfizer SARS-CoV-2 Impfstoffes - Bert Hubert's writings
a day ago
- The BioNTech/Pfizer SARS-CoV-2 mRNA vaccine (BNT162b2) consists of a digital code of 4284 characters, produced by a DNA printer and delivered as RNA in a lipid package.
- RNA is a fragile, RAM-like version of DNA; the vaccine's need for ultra-cold storage is due to RNA's instability.
- The vaccine code uses modified 'U' bases (1-Methyl-3'-Pseudouridylyl) to evade the immune system, a trick akin to cybersecurity bypassing firewalls.
- The 5' untranslated region (UTR) optimizes ribosome docking and protein translation, based on α-globin genome for high efficiency.
- A signal peptide directs the Spike protein to leave the cell via the endoplasmic reticulum, with codon optimization (more C and G bases) to enhance production.
- The Spike protein coding region features two proline substitutions that lock the protein in its active form, increasing vaccine efficacy against the actual virus.
- The 3' UTR and poly(A) tail of the mRNA enhance stability and translation efficiency, with a proprietary linker sequence for optimization.
- All modifications (codon optimization, U replacement, proline changes) are designed to increase RNA stability, evade immune detection, and produce a stable, immunogenic Spike protein.
Bu yazıda, BioNTech/Pfizer SARS-CoV-2 mRNA aşısının kaynak kodunu karakter karakter inceleyeceğiz - Bert Hubert's writings
a day ago
- BioNTech/Pfizer mRNA aşısının kaynak kodu 4284 karakter uzunluğundadır ve DNA yazıcısıyla fiziksel DNA'ya dönüştürülür.
- mRNA aşısı, SARS-CoV-2 spike proteinini üreterek bağışıklık sistemini eğitir ve %95 verimlilik sağlar.
- Aşının RNA'sında U yerine 1-methyl-3'-pseudouridylyl (Ψ) kullanılarak bağışıklık sisteminden kaçış sağlanır.
- 5' UTR bölgesi ribozomun bağlanması ve protein üretiminin başlaması için gerekli metadata içerir.
- Sinyal peptidi, spike proteinini hücre dışına yönlendirir ve kodon optimizasyonu ile daha verimli protein üretimi sağlanır.
- Spike proteinine iki prolin eklenerek proteinin kaynaşma öncesi yapısı korunur ve bağışıklık tepkisi optimize edilir.
- 3' UTR bölgesi ve poli(A) kuyruğu mRNA'nın stabilitesini ve ifade verimliliğini artırır.
Analiza izvornog kôda vakcine BioNTech-Pfizer SARS-CoV-2 - Bert Hubert's writings
a day ago
- The BioNTech/Pfizer vaccine is based on a 4284-character digital code that is synthesized into DNA and later converted into RNA for injection.
- mRNA vaccines teach the immune system to recognize the SARS-CoV-2 spike protein without causing illness, using a highly precise genetic approach.
- The vaccine uses a modified nucleotide, 1-methyl-3'-pseudouridine, to avoid immune detection while remaining functional in cells.
- The vaccine code includes a 5' untranslated region (UTR) for ribosome binding and a signal peptide to direct the spike protein to the endoplasmic reticulum.
- Most codons in the vaccine are synonymously optimized to include more G and C nucleotides, enhancing protein production efficiency.
- Two proline substitutions (K and V to P) in the spike protein stabilize it in a prefusion conformation, boosting vaccine effectiveness.
- The vaccine ends with a poly-A tail, including 30 A's, a 10-nucleotide linker, and 70 more A's, to protect mRNA from degradation.
- The entire vaccine is a codon-optimized, modified RNA sequence designed to produce a stable spike protein and trigger a strong immune response.

Hasty Briefsbeta

sars-cov-2

Dekonstruktion des Programmcodes des BioNTech/Pfizer SARS-CoV-2 Impfstoffes - Bert Hubert's writings

Bu yazıda, BioNTech/Pfizer SARS-CoV-2 mRNA aşısının kaynak kodunu karakter karakter inceleyeceğiz - Bert Hubert's writings

Analiza izvornog kôda vakcine BioNTech-Pfizer SARS-CoV-2 - Bert Hubert's writings