12 hours ago
- Acetaminophen (paracetamol) has a narrow therapeutic window, as taking too much (8 grams) can cause liver failure, but it is generally safer than ibuprofen when used as directed.
- Ibuprofen (an NSAID) poses risks to the stomach, heart, and kidneys due to systemic COX inhibition, including gastrointestinal ulcers, increased clotting, and kidney damage under certain conditions like dehydration.
- Acetaminophen is often safer than ibuprofen in most situations, including for people with liver disease, stomach ulcers, or heart conditions, though it should be avoided during fasting, heavy drinking, or hangovers.
- The U.S. FDA drug labels are well-crafted but do not compare the relative safety of different painkillers, and official sources avoid giving such comparative medical advice.