- Histamine in the brain improves memory accuracy by about 10% by enhancing novelty-linked arousal.
- The drug pitolisant, used for narcolepsy, increases brain histamine levels and boosts memory-related brain connectivity.
- Pitolisant is not recommended as a 'smart drug' due to potential sleep disruptions and long-term memory harm.
- Histamine receptors in the brain are linked to learning and memory, explaining side effects of older antihistamines.
- Research confirms histamine's role in memory applies to humans, supporting interest in treating brain conditions via histamine receptors.
- Pitolisant helps restore impaired cognitive function in diseases but does not enhance cognition beyond normal levels.