Team uses AlphaFold AI to redesign gene-editing proteins to make them safer
4 hours ago
- Gene editing therapies are emerging but face safety challenges due to off-target effects.
- Off-target effects occur because the human genome is large and even rare sequences can appear multiple times.
- Researchers used AlphaFold to identify and modify areas of Cas proteins responsible for off-target effects.
- Gene-editing components include guide RNA designed for specificity and improved Cas proteins to reduce off-target edits.