Team uses AlphaFold AI to redesign gene-editing proteins to make them safer

5 hours ago

Gene editing therapies are emerging but face safety challenges due to off-target effects.
Off-target effects occur because the human genome is large and even rare sequences can appear multiple times.
Researchers used AlphaFold to identify and modify areas of Cas proteins responsible for off-target effects.
Gene-editing components include guide RNA designed for specificity and improved Cas proteins to reduce off-target edits.

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