Een inkijkje in de broncode van het BioNTech/Pfizer SARS-CoV-2-vaccin - Bert Hubert's writings
a day ago
- The mRNA vaccine contains genetic code that instructs cells to produce the SARS-CoV-2 spike protein.
- The mRNA is modified with pseudouridine (1-methyl-3'-pseudouridylyl) to evade immune detection and enhance stability.
- The code includes a 5' cap, optimized 5' and 3' untranslated regions (UTRs), a signal peptide, and a codon-optimized spike protein sequence.
- Two proline substitutions in the spike protein stabilize it in the prefusion conformation, improving immune response.
- Codon optimization increases G and C content for higher protein expression efficiency.
- The poly-A tail has a unique linker sequence, possibly for further optimization.
- The vaccine leverages decades of research and is 95% effective.