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Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity - PubMed
6 days ago
- Lgr5+ hepatocytes are specialized cells involved in nutrient and xenobiotic metabolism, and DPF2 in these cells is essential for metabolic homeostasis.
- Loss of Dpf2 in Lgr5+ hepatocytes leads to severe MASLD by increasing CYP2 enzyme expression, which excessively metabolizes all-trans retinoic acid (atRA), reducing AMPK phosphorylation.
- Restoration of atRA rescues AMPK activity and reduces MASLD severity, revealing a non-cell-autonomous mechanism linking these hepatocytes to whole-liver regulation.
- DPF2 acts via the CYP2-atRA-AMPK axis, making atRA homeostasis a potential therapeutic target for MASLD and MASH.
- The findings highlight that chromatin regulation in spatially restricted cell populations can drive liver-wide metabolic reprogramming, suggesting targeted therapies.
The rise of bone marrow organoids as next-generation models for blood formation and failure - PubMed
6 days ago
- Bone marrow organoids (BMOs) are 3D culture models replicating bone marrow niche features.
- BMOs surpass classical models by better mimicking 3D architecture, cellular diversity, and spatial organization.
- They serve as scalable, cost-effective alternatives to animal models, reducing animal experimentation.
- iPSC-derived BMOs enable personalized disease modeling, drug testing, and gene editing for precise studies.
- Recent protocols by Christoph Klein and Abdullah Khan have advanced BMO generation and applications.
- BMOs are used to model inflammatory responses, genetic bone marrow failure syndromes, and multiple myeloma.
Rgn couples proliferative EGFR-JAK/STAT signaling and the notch/insulin differentiation-metabolism axis during epithelial repair in Drosophila - PubMed
6 days ago
- Rgn deficiency in Drosophila intestinal stem cells disrupts Notch signaling, leading to a loss of ISCs and accumulation of enteroblasts (EBs).
- This disruption suppresses the insulin/TOR pathway, causing reactive oxygen species (ROS) accumulation and DNA double-strand breaks.
- The resulting CHK2/p53-dependent G2/M arrest and apoptosis cause progenitor loss and intestinal atrophy.
- Overexpression of S6K rescues ROS accumulation and proliferation defects, while constitutive EGFR or STAT92E activation restores ISC mitotic activity.
- Rgn acts as an integrator of Notch-driven differentiation, insulin-dependent redox control, and DNA damage surveillance.
- The study establishes Drosophila Rgn as a functional analog of human REG proteins, suggesting potential therapies for inflammatory bowel diseases.
Design of binder proteins specific to IL-13 - PubMed
6 days ago
- Researchers used structure-based computational design to create compact minibinder proteins targeting IL-13, based on the IL-13-tralokinumab crystal structure.
- Five designed constructs were expressed in E. coli, with binder1 showing the strongest nanomolar binding affinity and most potent antagonism in IL-13-dependent proliferation assays (IC50 = 56.39 nM).
- Binder1 effectively suppressed STAT6 phosphorylation and reduced IL-13-induced pro-inflammatory gene expression in lung epithelial cells, indicating potential for topical immunotherapy in IL-13-related disorders.
Daratumumab, lenalidomide, and dexamethasone versus daratumumab, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma: A real-world propensity score-matched study - PubMed
6 days ago
- This real-world study compares DRd (daratumumab, lenalidomide, dexamethasone) and DVd (daratumumab, bortezomib, dexamethasone) in relapsed/refractory multiple myeloma (RRMM) using propensity score matching.
- Results show DRd significantly prolonged time to next treatment (median 32.6 vs. 17.7 months) and improved 5-year overall survival (58.4% vs. 52.3%) compared to DVd.
- DRd was associated with higher grade ≥3 neutropenia (27.7% vs. 12.5%), while DVd had higher grade ≥3 anemia (12.9% vs. 7.6%); other adverse events were infrequent (<10%).
- The study concludes that DRd offers superior effectiveness and manageable toxicity, suggesting it may be the preferred regimen for RRMM, warranting randomized head-to-head trials.
Enterotomy Outcomes in Abdominal Wall Reconstruction - PubMed
6 days ago
- Enterotomy (ENT) during abdominal wall reconstruction (AWR) is rare, occurring in 1.5% of cases in this study.
- ENT patients had higher rates of recurrent hernias, longer operative times, and increased length of hospital stay compared to non-ENT patients.
- Wound complications and hernia recurrence were significantly higher in the ENT group, with biologic mesh associated with lower wound complications but similar recurrence rates.
- Prevention of bowel injury and aggressive management of wound morbidity are emphasized for long-term AWR durability.
Multi-omics and machine learning reveal a critical mediator of PRKCA in quercetin-mediated protection against Sarcopenia - PubMed
6 days ago
- Quercetin intake is inversely and dose-dependently associated with sarcopenia risk, as identified through machine learning analysis of NHANES data.
- Mendelian randomization and multi-omics approaches link quercetin to the PRKCA gene, which mediates its protective effects against sarcopenia.
- Quercetin promotes myoblast differentiation by upregulating PRKCA and enhancing ERK1/2 phosphorylation, effects blocked by PRKCA inhibition.
- The study integrates epidemiological data, computational models, and experimental validation to elucidate quercetin's role in muscle health via PRKCA-ERK signaling.
Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions - PubMed
6 days ago
- Atractylodin (ATR), from Atractylodes lancea, improves obesity-related hepatic steatosis by enhancing lipid droplet-mitochondria interactions.
- ATR works by regulating the PLIN2-ATGL/CPT1A axis, promoting lipolysis and fatty acid oxidation in liver cells.
- In high-fat diet-induced mice and FFA-treated cell models, ATR reduced lipid accumulation and increased LD-mitochondria contacts.
Amyloid-Beta Immunotherapies for Alzheimer's Disease: Current Progress - PubMed
7 days ago
- Amyloid-Beta (Aβ) accumulation is a key factor in Alzheimer's Disease (AD) pathophysiology and progression.
- Immunotherapies targeting Aβ have emerged as potential disease-modifying drugs, with both active (vaccines) and passive (monoclonal antibodies) approaches developed.
- Early Aβ vaccines and monoclonal antibodies faced safety issues like ARIA and variable efficacy, leading to discontinuations but guiding refinements in later generations.
- Recent approvals include Aduhelm® (Aducanumab), Leqembi® (Lecanemab), and Kisunla® (Donanemab), which reduce Aβ burden and slow cognitive decline, though benefits are modest.
- Challenges remain in patient selection, biomarker monitoring, ARIA risk reduction, long-term outcomes, and global accessibility, with uncertainty about meaningful long-term disease modification.
Cardiogenic Shock Survivorship: A Multidisciplinary Approach Across the Continuum of Care - PubMed
7 days ago
- Cardiogenic shock (CS) survivors face high short-term mortality and long-term morbidity despite improvements in acute care.
- Current guidelines lack direction for post-acute care, highlighting a need for structured longitudinal approaches.
- The proposed Cardiogenic Shock Survivorship Continuum includes three phases: acute rescue, in-hospital optimization, and post-discharge care.
- Post-discharge care focuses on outpatient models, multidisciplinary clinics, risk stratification, and rehabilitation for functional recovery.
American Society of Breast Surgeons, Society of Breast Imaging, and College of American Pathology 2025 Guidelines for the Management of Infectious and Inflammatory Lesions of the Breast - PubMed
7 days ago
- Guidelines address three common infectious breast conditions: lactational mastitis (LM), granulomatous mastitis (GM), and periductal mastitis with squamous metaplasia of lactiferous ducts (PDM-SMOLD).
- For lactational mastitis, distinguish infectious from noninfectious: infectious LM may need stab incision with drain placement; if phlegmon is present, antibiotics for at least 10 days.
- Granulomatous mastitis requires core biopsy confirmation; cystic neutrophilic granulomatous mastitis (CNGM) is linked to Corynebacterium and should be treated empirically with doxycycline.
- GM cases can recur and take up to 18 months; worsening symptoms should be managed with repeated intralesional steroid injections, avoiding surgery or repeated aspirations.
- For PDM-SMOLD, treat with antibiotics and aspiration; operative excision is required for fistulas or recurrent episodes using a radial incision to remove diseased ducts.
Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription - PubMed
7 days ago
- Quadruple HFrEF therapy adoption increased in Sweden from 2016 to 2023, reaching 60% of patients by 2023.
- Patient adherence to all four foundational therapies was high (>85%), with persistence rates varying from 67% to 90% across drug classes.
- Good adherence and persistence were associated with lower rates of heart failure hospitalization and cardiovascular death.
- The main limitation in achieving full quadruple therapy uptake was lower adoption of mineralocorticoid receptor antagonists (MRA) at 73% in 2023.
- The study highlights that improvements in prescribing, adherence, and persistence are feasible in real-world heart failure care.
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses - PubMed
7 days ago
- SARS-CoV-2 evolves a truncated nucleocapsid protein, N*M210, due to acquisition of a viral transcription regulatory sequence (TRS) in the N gene, particularly in variants like Omicron, leading to increased production.
- N*M210 functions as a double-stranded RNA (dsRNA)-binding protein, inhibiting multiple antiviral responses by suppressing interferon, disassembling processing bodies, and blocking G3BP1 foci (e.g., stress granules and RNase L-dependent bodies).
- Enhanced N*M210 production boosts SARS-CoV-2 fitness in primary human cells and mice, as demonstrated with recombinant viruses, by evading dsRNA-induced antiviral responses and tipping cellular control in favor of the virus.
Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants - PubMed
7 days ago
- Complete biosynthesis of N,N-dimethyltryptamine (DMT) elucidated in hallucinogenic plants.
- Reconstructed pathways in a plant assay for five psychedelics: psilocin, psilocybin, DMT, bufotenin, and 5-methoxy-DMT.
- Engineered halogenated analogs with potential therapeutic use for psychiatric conditions.
- Enhanced production efficiency via cross-kingdom enzyme blending and metabolic engineering.
- Established a platform for concurrent biosynthesis and diversification of psychoactive tryptamines in plants.
Ginseng in exercise training and injury recovery: Composition, mechanism of action, dosage recommendations, and safety analysis - PubMed
7 days ago
- Ginseng (Panax ginseng) is used as an adaptogen in traditional medicine and sports nutrition.
- Bioactive components include ginsenosides, which enhance exercise performance via mitochondrial biogenesis through the AMPK/PGC-1α pathway, glycogen synthesis, lactate reduction, and improved VO₂max and endurance.
- Polysaccharides in ginseng provide antioxidant and immunomodulatory effects, reducing oxidative stress and fatigue.
- Clinical studies recommend daily supplementation of 200 to 400 mg of ginseng extract to optimize athletic performance, with individual tailoring possible.
- Ginseng has anti-inflammatory effects, reduces muscle damage markers, and supports muscle recovery, making it a multifunctional supplement for athletes.
- It is generally safe at recommended doses but may interact with anticoagulants; more clinical trials are needed for standardized guidelines.
Immunogenetic variants in major mental and neurodevelopmental disorders - PubMed
7 days ago
- Immunogenetic variants are linked to major mental and neurodevelopmental disorders, including bipolar disorder, recurrent depression, schizophrenia, autism spectrum disorders, and ADHD.
- Abnormal immune processes may cause chronic low-grade inflammation in some patients, leading to poor prognosis, treatment resistance, and functional decline.
- Interactions between immunogenetic factors and environmental risks (e.g., infections, pollution, stress) contribute to inflammation, emphasizing the need to understand immune genes and mechanisms for better patient stratification and treatment.
- Both innate and adaptive immunity genes play a role, with the Psychiatric Genomics Consortium identifying MHC-region associations in schizophrenia and bipolar disorders.
- Research aims to bridge gaps in knowledge to develop personalized therapeutic strategies based on immunogenetic information in immuno-psychiatry.
The impact of disease severity and symptoms on anxiety and depression in individuals with idiopathic pulmonary fibrosis - PubMed
7 days ago
- IPF is linked to high rates of anxiety (27.5%) and depression (28.2%).
- Worse dyspnea and lower energy are independent factors for anxiety and depression.
- Younger age is also associated with anxiety.
- Lung function (FVC%) did not correlate with anxiety or depression.
- Changes in anxiety relate to changes in dyspnea, cough, and energy over time.
- Mental health burden in IPF requires better recognition and symptom management.
Exercise biomarkers - PubMed
7 days ago
- The chapter discusses various biomarkers for monitoring endurance exercise effects on training adaptation, stress, recovery, and health.
- It covers biomarkers from cardiovascular, metabolic, hormonal, inflammatory, and neuromodulatory systems to understand physical activity's systemic impact.
- Key cardiovascular indicators include resting heart rate, heart rate variability, blood pressure, pulse wave velocity, and VO₂max for fitness and autonomic regulation.
- Emerging markers like oxidative stress, PGC-1α, and microRNAs provide insights into mitochondrial function and cellular adaptation to exercise.
- Neuromodulators such as β-endorphins, endocannabinoids, dopamine, serotonin, and BDNF are linked to the Runner's High and affect mood, perception, and pain sensitivity.
- Challenges in biomarker application include interindividual variability, timing of sampling, and practical implementation in clinical and athletic settings.
- These biomarkers offer an integrative framework for evaluating endurance training, optimizing performance, and supporting preventive health strategies.
Influence of USP15 and its derived-peptide on non-small cell lung cancer immune evasion via regulating PD-L1 stability - PubMed
7 days ago
- USP15 acts as a deubiquitinase that stabilizes PD-L1 by inhibiting its ubiquitination and degradation in NSCLC cells.
- USP15 promotes NSCLC immune evasion by reducing CD8+ T cell population and activation in the tumor microenvironment.
- A derived peptide U10 disrupts USP15-PD-L1 interaction, degrades PD-L1, and suppresses NSCLC immune escape.
- U10 enhances the anti-NSCLC effect of PD-1 monoclonal antibody in mouse models.
- USP15 and PD-L1 expression levels are higher in NSCLC tissues and positively correlated, predicting immunotherapy efficacy and prognosis.
Highlights in IO: next-generation CAR-T therapy for glioblastoma - PubMed
7 days ago
- Phase 1 clinical trials of CAR-T cell therapies for glioblastoma (GBM) have been reported.
- Challenges for CAR-T therapy in GBM include immunosuppressive microenvironment, antigen heterogeneity, and anatomical isolation.
- Next-generation CAR-T cells with additional functionalities are being developed and tested in phase 1 trials.
- Antitumor efficacy needs improvement, and neurotoxicity remains a major issue.
- There is growing anticipation that next-generation CAR-T therapies may benefit patients.

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Bilingual

Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity - PubMed
6 days ago
- Lgr5+ hepatocytes are specialized cells involved in nutrient and xenobiotic metabolism, and DPF2 in these cells is essential for metabolic homeostasis.
- Loss of Dpf2 in Lgr5+ hepatocytes leads to severe MASLD by increasing CYP2 enzyme expression, which excessively metabolizes all-trans retinoic acid (atRA), reducing AMPK phosphorylation.
- Restoration of atRA rescues AMPK activity and reduces MASLD severity, revealing a non-cell-autonomous mechanism linking these hepatocytes to whole-liver regulation.
- DPF2 acts via the CYP2-atRA-AMPK axis, making atRA homeostasis a potential therapeutic target for MASLD and MASH.
- The findings highlight that chromatin regulation in spatially restricted cell populations can drive liver-wide metabolic reprogramming, suggesting targeted therapies.
The rise of bone marrow organoids as next-generation models for blood formation and failure - PubMed
6 days ago
- Bone marrow organoids (BMOs) are 3D culture models replicating bone marrow niche features.
- BMOs surpass classical models by better mimicking 3D architecture, cellular diversity, and spatial organization.
- They serve as scalable, cost-effective alternatives to animal models, reducing animal experimentation.
- iPSC-derived BMOs enable personalized disease modeling, drug testing, and gene editing for precise studies.
- Recent protocols by Christoph Klein and Abdullah Khan have advanced BMO generation and applications.
- BMOs are used to model inflammatory responses, genetic bone marrow failure syndromes, and multiple myeloma.
Rgn couples proliferative EGFR-JAK/STAT signaling and the notch/insulin differentiation-metabolism axis during epithelial repair in Drosophila - PubMed
6 days ago
- Rgn deficiency in Drosophila intestinal stem cells disrupts Notch signaling, leading to a loss of ISCs and accumulation of enteroblasts (EBs).
- This disruption suppresses the insulin/TOR pathway, causing reactive oxygen species (ROS) accumulation and DNA double-strand breaks.
- The resulting CHK2/p53-dependent G2/M arrest and apoptosis cause progenitor loss and intestinal atrophy.
- Overexpression of S6K rescues ROS accumulation and proliferation defects, while constitutive EGFR or STAT92E activation restores ISC mitotic activity.
- Rgn acts as an integrator of Notch-driven differentiation, insulin-dependent redox control, and DNA damage surveillance.
- The study establishes Drosophila Rgn as a functional analog of human REG proteins, suggesting potential therapies for inflammatory bowel diseases.
Design of binder proteins specific to IL-13 - PubMed
6 days ago
- Researchers used structure-based computational design to create compact minibinder proteins targeting IL-13, based on the IL-13-tralokinumab crystal structure.
- Five designed constructs were expressed in E. coli, with binder1 showing the strongest nanomolar binding affinity and most potent antagonism in IL-13-dependent proliferation assays (IC50 = 56.39 nM).
- Binder1 effectively suppressed STAT6 phosphorylation and reduced IL-13-induced pro-inflammatory gene expression in lung epithelial cells, indicating potential for topical immunotherapy in IL-13-related disorders.
Daratumumab, lenalidomide, and dexamethasone versus daratumumab, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma: A real-world propensity score-matched study - PubMed
6 days ago
- This real-world study compares DRd (daratumumab, lenalidomide, dexamethasone) and DVd (daratumumab, bortezomib, dexamethasone) in relapsed/refractory multiple myeloma (RRMM) using propensity score matching.
- Results show DRd significantly prolonged time to next treatment (median 32.6 vs. 17.7 months) and improved 5-year overall survival (58.4% vs. 52.3%) compared to DVd.
- DRd was associated with higher grade ≥3 neutropenia (27.7% vs. 12.5%), while DVd had higher grade ≥3 anemia (12.9% vs. 7.6%); other adverse events were infrequent (<10%).
- The study concludes that DRd offers superior effectiveness and manageable toxicity, suggesting it may be the preferred regimen for RRMM, warranting randomized head-to-head trials.
Enterotomy Outcomes in Abdominal Wall Reconstruction - PubMed
6 days ago
- Enterotomy (ENT) during abdominal wall reconstruction (AWR) is rare, occurring in 1.5% of cases in this study.
- ENT patients had higher rates of recurrent hernias, longer operative times, and increased length of hospital stay compared to non-ENT patients.
- Wound complications and hernia recurrence were significantly higher in the ENT group, with biologic mesh associated with lower wound complications but similar recurrence rates.
- Prevention of bowel injury and aggressive management of wound morbidity are emphasized for long-term AWR durability.
Multi-omics and machine learning reveal a critical mediator of PRKCA in quercetin-mediated protection against Sarcopenia - PubMed
6 days ago
- Quercetin intake is inversely and dose-dependently associated with sarcopenia risk, as identified through machine learning analysis of NHANES data.
- Mendelian randomization and multi-omics approaches link quercetin to the PRKCA gene, which mediates its protective effects against sarcopenia.
- Quercetin promotes myoblast differentiation by upregulating PRKCA and enhancing ERK1/2 phosphorylation, effects blocked by PRKCA inhibition.
- The study integrates epidemiological data, computational models, and experimental validation to elucidate quercetin's role in muscle health via PRKCA-ERK signaling.
Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions - PubMed
6 days ago
- Atractylodin (ATR), from Atractylodes lancea, improves obesity-related hepatic steatosis by enhancing lipid droplet-mitochondria interactions.
- ATR works by regulating the PLIN2-ATGL/CPT1A axis, promoting lipolysis and fatty acid oxidation in liver cells.
- In high-fat diet-induced mice and FFA-treated cell models, ATR reduced lipid accumulation and increased LD-mitochondria contacts.
Amyloid-Beta Immunotherapies for Alzheimer's Disease: Current Progress - PubMed
7 days ago
- Amyloid-Beta (Aβ) accumulation is a key factor in Alzheimer's Disease (AD) pathophysiology and progression.
- Immunotherapies targeting Aβ have emerged as potential disease-modifying drugs, with both active (vaccines) and passive (monoclonal antibodies) approaches developed.
- Early Aβ vaccines and monoclonal antibodies faced safety issues like ARIA and variable efficacy, leading to discontinuations but guiding refinements in later generations.
- Recent approvals include Aduhelm® (Aducanumab), Leqembi® (Lecanemab), and Kisunla® (Donanemab), which reduce Aβ burden and slow cognitive decline, though benefits are modest.
- Challenges remain in patient selection, biomarker monitoring, ARIA risk reduction, long-term outcomes, and global accessibility, with uncertainty about meaningful long-term disease modification.
Cardiogenic Shock Survivorship: A Multidisciplinary Approach Across the Continuum of Care - PubMed
7 days ago
- Cardiogenic shock (CS) survivors face high short-term mortality and long-term morbidity despite improvements in acute care.
- Current guidelines lack direction for post-acute care, highlighting a need for structured longitudinal approaches.
- The proposed Cardiogenic Shock Survivorship Continuum includes three phases: acute rescue, in-hospital optimization, and post-discharge care.
- Post-discharge care focuses on outpatient models, multidisciplinary clinics, risk stratification, and rehabilitation for functional recovery.
American Society of Breast Surgeons, Society of Breast Imaging, and College of American Pathology 2025 Guidelines for the Management of Infectious and Inflammatory Lesions of the Breast - PubMed
7 days ago
- Guidelines address three common infectious breast conditions: lactational mastitis (LM), granulomatous mastitis (GM), and periductal mastitis with squamous metaplasia of lactiferous ducts (PDM-SMOLD).
- For lactational mastitis, distinguish infectious from noninfectious: infectious LM may need stab incision with drain placement; if phlegmon is present, antibiotics for at least 10 days.
- Granulomatous mastitis requires core biopsy confirmation; cystic neutrophilic granulomatous mastitis (CNGM) is linked to Corynebacterium and should be treated empirically with doxycycline.
- GM cases can recur and take up to 18 months; worsening symptoms should be managed with repeated intralesional steroid injections, avoiding surgery or repeated aspirations.
- For PDM-SMOLD, treat with antibiotics and aspiration; operative excision is required for fistulas or recurrent episodes using a radial incision to remove diseased ducts.
Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription - PubMed
7 days ago
- Quadruple HFrEF therapy adoption increased in Sweden from 2016 to 2023, reaching 60% of patients by 2023.
- Patient adherence to all four foundational therapies was high (>85%), with persistence rates varying from 67% to 90% across drug classes.
- Good adherence and persistence were associated with lower rates of heart failure hospitalization and cardiovascular death.
- The main limitation in achieving full quadruple therapy uptake was lower adoption of mineralocorticoid receptor antagonists (MRA) at 73% in 2023.
- The study highlights that improvements in prescribing, adherence, and persistence are feasible in real-world heart failure care.
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses - PubMed
7 days ago
- SARS-CoV-2 evolves a truncated nucleocapsid protein, N*M210, due to acquisition of a viral transcription regulatory sequence (TRS) in the N gene, particularly in variants like Omicron, leading to increased production.
- N*M210 functions as a double-stranded RNA (dsRNA)-binding protein, inhibiting multiple antiviral responses by suppressing interferon, disassembling processing bodies, and blocking G3BP1 foci (e.g., stress granules and RNase L-dependent bodies).
- Enhanced N*M210 production boosts SARS-CoV-2 fitness in primary human cells and mice, as demonstrated with recombinant viruses, by evading dsRNA-induced antiviral responses and tipping cellular control in favor of the virus.
Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants - PubMed
7 days ago
- Complete biosynthesis of N,N-dimethyltryptamine (DMT) elucidated in hallucinogenic plants.
- Reconstructed pathways in a plant assay for five psychedelics: psilocin, psilocybin, DMT, bufotenin, and 5-methoxy-DMT.
- Engineered halogenated analogs with potential therapeutic use for psychiatric conditions.
- Enhanced production efficiency via cross-kingdom enzyme blending and metabolic engineering.
- Established a platform for concurrent biosynthesis and diversification of psychoactive tryptamines in plants.
Ginseng in exercise training and injury recovery: Composition, mechanism of action, dosage recommendations, and safety analysis - PubMed
7 days ago
- Ginseng (Panax ginseng) is used as an adaptogen in traditional medicine and sports nutrition.
- Bioactive components include ginsenosides, which enhance exercise performance via mitochondrial biogenesis through the AMPK/PGC-1α pathway, glycogen synthesis, lactate reduction, and improved VO₂max and endurance.
- Polysaccharides in ginseng provide antioxidant and immunomodulatory effects, reducing oxidative stress and fatigue.
- Clinical studies recommend daily supplementation of 200 to 400 mg of ginseng extract to optimize athletic performance, with individual tailoring possible.
- Ginseng has anti-inflammatory effects, reduces muscle damage markers, and supports muscle recovery, making it a multifunctional supplement for athletes.
- It is generally safe at recommended doses but may interact with anticoagulants; more clinical trials are needed for standardized guidelines.
Immunogenetic variants in major mental and neurodevelopmental disorders - PubMed
7 days ago
- Immunogenetic variants are linked to major mental and neurodevelopmental disorders, including bipolar disorder, recurrent depression, schizophrenia, autism spectrum disorders, and ADHD.
- Abnormal immune processes may cause chronic low-grade inflammation in some patients, leading to poor prognosis, treatment resistance, and functional decline.
- Interactions between immunogenetic factors and environmental risks (e.g., infections, pollution, stress) contribute to inflammation, emphasizing the need to understand immune genes and mechanisms for better patient stratification and treatment.
- Both innate and adaptive immunity genes play a role, with the Psychiatric Genomics Consortium identifying MHC-region associations in schizophrenia and bipolar disorders.
- Research aims to bridge gaps in knowledge to develop personalized therapeutic strategies based on immunogenetic information in immuno-psychiatry.
The impact of disease severity and symptoms on anxiety and depression in individuals with idiopathic pulmonary fibrosis - PubMed
7 days ago
- IPF is linked to high rates of anxiety (27.5%) and depression (28.2%).
- Worse dyspnea and lower energy are independent factors for anxiety and depression.
- Younger age is also associated with anxiety.
- Lung function (FVC%) did not correlate with anxiety or depression.
- Changes in anxiety relate to changes in dyspnea, cough, and energy over time.
- Mental health burden in IPF requires better recognition and symptom management.
Exercise biomarkers - PubMed
7 days ago
- The chapter discusses various biomarkers for monitoring endurance exercise effects on training adaptation, stress, recovery, and health.
- It covers biomarkers from cardiovascular, metabolic, hormonal, inflammatory, and neuromodulatory systems to understand physical activity's systemic impact.
- Key cardiovascular indicators include resting heart rate, heart rate variability, blood pressure, pulse wave velocity, and VO₂max for fitness and autonomic regulation.
- Emerging markers like oxidative stress, PGC-1α, and microRNAs provide insights into mitochondrial function and cellular adaptation to exercise.
- Neuromodulators such as β-endorphins, endocannabinoids, dopamine, serotonin, and BDNF are linked to the Runner's High and affect mood, perception, and pain sensitivity.
- Challenges in biomarker application include interindividual variability, timing of sampling, and practical implementation in clinical and athletic settings.
- These biomarkers offer an integrative framework for evaluating endurance training, optimizing performance, and supporting preventive health strategies.
Influence of USP15 and its derived-peptide on non-small cell lung cancer immune evasion via regulating PD-L1 stability - PubMed
7 days ago
- USP15 acts as a deubiquitinase that stabilizes PD-L1 by inhibiting its ubiquitination and degradation in NSCLC cells.
- USP15 promotes NSCLC immune evasion by reducing CD8+ T cell population and activation in the tumor microenvironment.
- A derived peptide U10 disrupts USP15-PD-L1 interaction, degrades PD-L1, and suppresses NSCLC immune escape.
- U10 enhances the anti-NSCLC effect of PD-1 monoclonal antibody in mouse models.
- USP15 and PD-L1 expression levels are higher in NSCLC tissues and positively correlated, predicting immunotherapy efficacy and prognosis.
Highlights in IO: next-generation CAR-T therapy for glioblastoma - PubMed
7 days ago
- Phase 1 clinical trials of CAR-T cell therapies for glioblastoma (GBM) have been reported.
- Challenges for CAR-T therapy in GBM include immunosuppressive microenvironment, antigen heterogeneity, and anatomical isolation.
- Next-generation CAR-T cells with additional functionalities are being developed and tested in phase 1 trials.
- Antitumor efficacy needs improvement, and neurotoxicity remains a major issue.
- There is growing anticipation that next-generation CAR-T therapies may benefit patients.

Hasty Briefsbeta

Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity - PubMed

The rise of bone marrow organoids as next-generation models for blood formation and failure - PubMed

Rgn couples proliferative EGFR-JAK/STAT signaling and the notch/insulin differentiation-metabolism axis during epithelial repair in Drosophila - PubMed

Design of binder proteins specific to IL-13 - PubMed

Daratumumab, lenalidomide, and dexamethasone versus daratumumab, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma: A real-world propensity score-matched study - PubMed

Enterotomy Outcomes in Abdominal Wall Reconstruction - PubMed

Multi-omics and machine learning reveal a critical mediator of PRKCA in quercetin-mediated protection against Sarcopenia - PubMed

Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions - PubMed

Amyloid-Beta Immunotherapies for Alzheimer's Disease: Current Progress - PubMed

Cardiogenic Shock Survivorship: A Multidisciplinary Approach Across the Continuum of Care - PubMed

American Society of Breast Surgeons, Society of Breast Imaging, and College of American Pathology 2025 Guidelines for the Management of Infectious and Inflammatory Lesions of the Breast - PubMed

Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription - PubMed

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses - PubMed

Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants - PubMed

Ginseng in exercise training and injury recovery: Composition, mechanism of action, dosage recommendations, and safety analysis - PubMed

Immunogenetic variants in major mental and neurodevelopmental disorders - PubMed

The impact of disease severity and symptoms on anxiety and depression in individuals with idiopathic pulmonary fibrosis - PubMed

Exercise biomarkers - PubMed

Influence of USP15 and its derived-peptide on non-small cell lung cancer immune evasion via regulating PD-L1 stability - PubMed

Highlights in IO: next-generation CAR-T therapy for glioblastoma - PubMed

Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity - PubMed

The rise of bone marrow organoids as next-generation models for blood formation and failure - PubMed

Rgn couples proliferative EGFR-JAK/STAT signaling and the notch/insulin differentiation-metabolism axis during epithelial repair in Drosophila - PubMed

Design of binder proteins specific to IL-13 - PubMed

Daratumumab, lenalidomide, and dexamethasone versus daratumumab, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma: A real-world propensity score-matched study - PubMed

Enterotomy Outcomes in Abdominal Wall Reconstruction - PubMed

Multi-omics and machine learning reveal a critical mediator of PRKCA in quercetin-mediated protection against Sarcopenia - PubMed

Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions - PubMed

Amyloid-Beta Immunotherapies for Alzheimer's Disease: Current Progress - PubMed

Cardiogenic Shock Survivorship: A Multidisciplinary Approach Across the Continuum of Care - PubMed

American Society of Breast Surgeons, Society of Breast Imaging, and College of American Pathology 2025 Guidelines for the Management of Infectious and Inflammatory Lesions of the Breast - PubMed

Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription - PubMed

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses - PubMed

Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants - PubMed

Ginseng in exercise training and injury recovery: Composition, mechanism of action, dosage recommendations, and safety analysis - PubMed

Immunogenetic variants in major mental and neurodevelopmental disorders - PubMed

The impact of disease severity and symptoms on anxiety and depression in individuals with idiopathic pulmonary fibrosis - PubMed

Exercise biomarkers - PubMed

Influence of USP15 and its derived-peptide on non-small cell lung cancer immune evasion via regulating PD-L1 stability - PubMed

Highlights in IO: next-generation CAR-T therapy for glioblastoma - PubMed