Hasty Briefsbeta

All tags

#ferroptosis

191 stories total

Bilingual

Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunction via ALOX15-Mediated Ferroptosis - PubMed
2 months ago
- Cigarette smoke (CS) exacerbates right ventricular (RV) dysfunction in pressure overload conditions via ALOX15-mediated ferroptosis.
- A rat model of pulmonary artery banding (PAB) combined with CS exposure showed worsened RV function, hypertrophy, fibrosis, and capillary rarefaction.
- Transcriptomic analysis identified activation of the ALOX15-ferroptosis pathway in RV tissue from CS-exposed PAB rats.
- ALOX15 was predominantly localized in cardiomyocytes, and its inhibition reduced cardiac stress markers ANP and BNP.
- The study suggests ALOX15-mediated ferroptosis as a key mechanism and potential therapeutic target for RV dysfunction in COPD-PH.
Yitangkang decoction in the treatment of glomerular filtration barrier damage through AMPKα1/ZDHHC8/SLC7A11/GPX4 and TGF-β/Smad signaling pathways: A multi-omics analysis - PubMed
2 months ago
- Yitangkang decoction (YTK) shows potential in treating glomerular filtration barrier damage in diabetic kidney disease (DKD).
- YTK works through multiple pathways including AMPKα1/ZDHHC8/SLC7A11/GPX4 and TGF-β/Smad signaling.
- Multi-omics analysis reveals YTK's mechanisms: inhibiting TGF-β/Smad pathway, enhancing SLC7A11 palmitoylation, modulating macrophage polarization, and providing multi-target cytoprotection.
- YTK reduces urinary albumin-to-creatinine ratio (UACR), serum creatinine, urea, uric acid, and lipid peroxide levels while restoring glutathione levels.
- Key active components puerarin and quercitrin bind directly to GPX4 and TGF-β1, mediating YTK's therapeutic effects.
- YTK represents a promising multi-target therapeutic strategy for DKD by balancing injury and protective signaling pathways.
Identification of Ferroptosis-Related Hub Genes and Immune Infiltration Landscape in Chronic Kidney Disease via Bioinformatics and Experimental Verification - PubMed
2 months ago
- Chronic kidney disease (CKD) is a serious global health issue with increasing incidence.
- Ferroptosis plays a crucial role in kidney diseases, but its mechanism in CKD is not well understood.
- The study identified 7 ferroptosis-related hub genes (NNMT, GDF15, ACSL1, DLD, NFE2L2, PARP1, NR4A1) using bioinformatics tools like WGCNA, PPI, and GeneMANIA.
- These hub genes were validated and showed a clear link to renal function deterioration.
- ROC analysis demonstrated excellent diagnostic efficacy for these genes.
- Gene set enrichment analysis (GSEA) suggested these genes affect CKD through posttranscriptional modifications, immune dysfunction, and cell cycle dysregulation.
- CKD samples showed elevated levels of CD8+ T cells and M0 macrophages, while memory B cells, resting memory CD4+ T cells, Tregs, and resting mast cells decreased.
- In vitro experiments confirmed upregulation of NFE2L2, NNMT, and GDF15 in TGF-β1-treated HK-2 cells.
- The study suggests these hub genes as potential biomarkers and novel targets for CKD diagnosis and treatment.
Ferroptosis-autophagy crosstalk in bladder cancer: mechanisms and therapeutic implications - PubMed
2 months ago
- The article discusses the interaction between ferroptosis and autophagy in bladder cancer (BC).
- It explores the mechanisms behind this crosstalk and its potential therapeutic implications.
- The study references multiple sources, including clinical trials and genomic profiling of bladder cancer.
- No competing interests were declared by the authors.
- Key references include studies on marker-guided surveillance, neuroendocrine bladder cancer, and nano drug delivery systems for BC treatment.
Hippocampal Neuronal Ferroptosis Driven by Lipocalin-2 Mediates Comorbid Visceral Pain and Anxiety in Irritable Bowel Syndrome - PubMed
2 months ago
- Hippocampal Lipocalin-2 (LCN2) drives neuronal ferroptosis in IBS.
- LCN2-mediated ferroptosis links visceral pain and anxiety in IBS.
- Ferroptosis inhibition reverses pain and anxiety-like behaviors in IBS models.
- LCN2 knockdown in hippocampal CA1 alleviates IBS symptoms.
- Study identifies LCN2-ferroptosis axis as a new therapeutic target for IBS.
Targeting the Keap1-Nrf2/GPX4 axis to suppress ferroptosis in acute lung injury - PubMed
2 months ago
- Acute lung injury (ALI) is a severe condition with high mortality and limited treatment options.
- Kaempferol-3-O-α-L-(4″-E-p-coumaroyl)-rhamnoside (KAE) from Angelica acutiloba Kitagawa flowers reduces inflammation and oxidative stress in ALI.
- KAE binds to Keap1 at Arg415, disrupting Keap1-Nrf2 interaction, promoting Nrf2 nuclear translocation, and activating antioxidant and anti-ferroptosis pathways.
- Mutation at Keap1 Arg415 prevents KAE's therapeutic effects, highlighting its critical role.
- KAE shows promise as a therapeutic agent for ALI by targeting the Keap1-Nrf2/GPX4 axis.
ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucl
2 months ago
- Intervertebral disc degeneration (IVDD) causes cervical spondylosis and low back pain, leading to clinical disability.
- Excessive reactive oxygen species (ROS) drive IVDD, but mechanisms linking ROS to disc cell dysfunction remain unclear.
- A 'ROS-Mitochondrial dysfunction-Ferritinophagy' oxidative stress feedback loop is identified as central to ROS-induced nucleus pulposus cell (NPC) ferroptosis in IVDD.
- ADGRG1 is a biomarker of ROS-induced ferroptosis in injured NPCs.
- ADGRG1-tethered peptide (A1TP)-modified hypoxia preconditioned extracellular vesicles (HX-EVs) were developed for targeted antioxidant therapy.
- HX-EVs deliver taurine, which binds to LKB1 and MO25 residues, facilitating the assembly of the LKB1-STRAD-MO25 kinase complex.
- This interaction activates the AMPK/NRF2 pathway, suppressing ferritinophagy, enhancing mitochondrial repair, and protecting NPCs from ferroptosis.
- The A1TP-HX-EV system shows promise for IVDD treatment and provides insights into targeted HX-EV delivery and disc regeneration.
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mechanisms - PubMed
2 months ago
- Sorafenib is a key treatment for advanced hepatocellular carcinoma (HCC), but resistance often limits its effectiveness.
- Ferroptosis, an iron-dependent cell death process, is a promising target to overcome sorafenib resistance.
- The Nrf2/SLC7A11/GPX4 antioxidant axis plays a crucial role in protecting HCC cells from ferroptosis.
- Other pathways like FSP1-CoQ10 and ACSL4/LPCAT3 also regulate ferroptosis in sorafenib-resistant HCC.
- Transcriptional regulators such as P53, ATF4, SAT1, and ABCC5 influence SLC7A11 and ferroptosis pathways.
- Targeting these molecular mechanisms could lead to new therapies to resensitize HCC to sorafenib.
The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis - PubMed
2 months ago
- Maclekarpine E (ME) shows potential as a treatment for ulcerative colitis (UC) by targeting ferroptosis.
- ME was prepared via a semi-synthetic and biomimetic route and tested in both in vitro and in vivo models.
- Proteomic analysis revealed ME inhibits ferroptosis by up-regulating the NRF2/GPX4 antioxidant axis and down-regulating ACSL4.
- ME binds to OTUD4, reducing GPX4 ubiquitination and enhancing its stability.
- The study suggests ME as a promising lead compound and OTUD4 as a potential new target for anti-inflammatory drugs.
Sodium Butyrate Alleviates IBD by Modulating SIRT1-Involved Ferroptosis and Inhibition of Macrophage Ferroptosis - PubMed
2 months ago
- Sodium butyrate (NaB) alleviates inflammatory bowel disease (IBD) symptoms in mice.
- NaB modulates SIRT1-associated signaling molecules to inhibit ferroptosis.
- NaB downregulates ACSL4 and upregulates GPX4 and SLC7A11, indicating ferroptosis inhibition.
- Immunofluorescence staining shows increased GPX4 expression in macrophages with NaB treatment.
- The study suggests NaB's potential as a therapeutic agent for IBD by targeting ferroptosis pathways.
FBR-NDs: a ferroptosis-inducing nanocomplex for targeted breast cancer therapy via immune modulation and redox-responsive drug delivery - PubMed
2 months ago
- FBR-NDs are a novel ferroptosis-inducing nanocomplex designed for targeted breast cancer therapy.
- The nanocomplex was synthesized via nanoprecipitation and characterized using TEM, XPS, and FT-IR spectroscopy.
- FBR-NDs demonstrated redox-responsive drug release under acidic pH and GSH conditions.
- In vitro studies showed significant inhibition of breast cancer cell proliferation and induction of ferroptosis.
- In vivo studies in a 4T1 breast cancer mouse model confirmed reduced tumor growth and enhanced immune responses.
- FBR-NDs promoted infiltration of immune cells like dendritic cells and M1 macrophages, and activated T-cells.
- The study suggests FBR-NDs as a promising therapeutic strategy combining ferroptosis induction and immune modulation.
DPP4 suppresses pancreatic cancer growth by enhancing ferroptosis sensitivity through stabilization of ACSL4 - PubMed
2 months ago
- DPP4 expression is significantly downregulated in pancreatic ductal adenocarcinoma (PDAC) tumor tissues compared to adjacent non-tumorous tissues.
- DPP4 overexpression in PDAC cell lines inhibits cell proliferation, induces G1-S cell cycle arrest, and sensitizes cells to erastin-induced ferroptosis.
- DPP4 stabilizes ACSL4 by inhibiting its ubiquitin-mediated degradation, promoting ACSL4-dependent lipid peroxidation.
- ACSL4 knockdown rescues DPP4 overexpression-induced ferroptosis and lipid ROS accumulation.
- The DPP4-ACSL4 axis is identified as a potential therapeutic target to enhance ferroptosis-based strategies against PDAC.
ALDH1L2 induces resistance to chemotherapy in small cell lung cancer by inhibiting ferroptosis - PubMed
2 months ago
- ALDH1L2 expression is linked to poor prognosis in small cell lung cancer (SCLC).
- High ALDH1L2 levels inhibit ferroptosis by reducing cellular lipid peroxidation, leading to chemoresistance.
- ALDH1L2 interacts with the TRX2-PRDX3 antioxidant network to decrease oxidized PRDX3 levels under cisplatin-induced stress.
- Thiostrepton, a PRDX3 inhibitor, shows potential in overcoming SCLC chemoresistance when combined with chemotherapy.
Hyodeoxycholic acid in Arisaema Cum Bile can alleviate pentylenetetrazol-induced epilepsy by activating p53/Nrf2/GPX4 to inhibit ferroptosis - PubMed
2 months ago
- Hyodeoxycholic acid (HDCA) in Arisaema Cum Bile (ACB) alleviates pentylenetetrazol-induced epilepsy by inhibiting ferroptosis via the p53/Nrf2/GPX4 pathway.
- ACB, a traditional Chinese medicine, contains 37 chemical components, with 10 crossing the blood-brain barrier, including steroids and terpenoids.
- HDCA is identified as a key active component in ACB, reducing seizure frequency and severity in epileptic rats and improving cognitive function.
- In vitro studies show HDCA inhibits glutamate-induced ferroptosis in HT22 neurons, with effects mediated by Nrf2 activation.
- The study provides evidence for ACB and HDCA as potential treatments for epilepsy by targeting ferroptosis-related pathways.
Molecularly Engineered Phenoxazinone-Skeleton Cascade-Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis-Mediated Parkinson's Disease - PubMed
2 months ago
- Parkinson's disease (PD) is the second most common neurodegenerative disease, with ferroptosis potentially leading to dopaminergic neuron death.
- Accumulated ferrous ions (Fe2+) and increased intracellular viscosity promote ferroptosis, making monitoring Fe2+/viscosity crucial for PD theranostics.
- A series of Fe2+/viscosity cascade-activated near-infrared fluorescence probes (NP1-5) were synthesized, with NP3 identified as the optimal probe.
- NP3 monitors Fe2+/viscosity via redox reactions and twisted intramolecular charge transfer processes.
- An innovative nanoplatform (PQR NPs) was constructed using NP3 and quercetin, modified with rabies virus glycoprotein-29.
- PQR NPs alleviate ferroptosis-induced neuron loss by reducing oxidative stress, neuroinflammation, mitigating α-synuclein aggregation, and restoring mitochondrial function.
- PQR NPs also monitor elevated Fe2+/viscosity in PD models, offering potential for PD and other ferroptosis-related diseases.
Retraction notice to "Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling" [Biomedicine & Pharmacotherapy 169 (2023) 115895] - PubMed
2 months ago
- Retraction notice for the article 'Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling'.
- Originally published in Biomedicine & Pharmacotherapy, Volume 169, 2023, Article ID 115895.
- Retraction published in Biomedicine & Pharmacotherapy, 2026, DOI: 10.1016/j.biopha.2026.119178.
- PMID for the original article: 37984309.
- Retraction PMID: 41763913.
Acteoside targeting glutamine synthetase ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis - PubMed
2 months ago
- Acteoside (ACT) is a bioactive compound that shows potential in treating doxorubicin-induced cardiotoxicity (DIC).
- Glutamine synthetase (GS) was identified as a key pathological driver in DIC through proteomic profiling.
- ACT was found to directly inhibit GS, preventing glutamate depletion and restoring the GLU-GSH-GPX4 antioxidant axis.
- By inhibiting GS, ACT suppresses lipid peroxidation and ferroptosis, both in vitro and in vivo.
- ACT administration significantly reduced DOX-induced cardiac dysfunction, fibrosis, and myocardial atrophy.
- The study suggests ACT as a promising natural compound for managing DIC by targeting ferroptosis.
STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1 - PubMed
2 months ago
- STING1 exacerbates iodinated contrast-induced acute kidney injury (CI-AKI) by promoting ferroptosis.
- Ferroptosis is driven by iron overload and lipid peroxidation, contributing to CI-AKI.
- STING1 activation by iodinated contrast media (ICM) triggers ferroptosis in renal proximal tubular cells (RPTCs).
- Sting1 deficiency in knockout mice and primary RPTCs mitigates ferroptosis and alleviates CI-AKI.
- STING1 interacts with HSPA8/HSC70, facilitating chaperone-mediated autophagic degradation of FTH1 and GPX4.
- Inhibition of chaperone-mediated autophagy (CMA) via LAMP2A knockdown prevents FTH1 and GPX4 degradation, reducing ferroptosis.
- The study highlights STING1 as a potential therapeutic target for contrast-induced renal injury.
Proteolysis-Targeting Chimeras Induce Ferroptosis in Cancer: From Mechanism to Clinical Application - PubMed
2 months ago
- Ferroptosis is an iron-dependent cell death mechanism important for tumor suppression.
- Clinical application of ferroptosis is limited by regulatory complexity and lack of selective modulators.
- PROTACs offer a precise way to manipulate ferroptosis pathways.
- Key regulatory pathways include GPX4, FSP1, and DHODH.
- PROTAC design strategies focus on targeting these key nodes, with current efforts mainly on GPX4.
- Challenges include PROTAC druggability, ferroptosis's dual role, and compensatory resistance.
- Future strategies involve multi-target degraders, smart drug delivery, and combination therapies.
- Computational tools and AI are highlighted for accelerating PROTAC design.
- PROTAC technology has potential to treat refractory cancers by reactivating ferroptosis.
Lipid metabolism drives dietary effects on T cell ferroptosis and immunity - PubMed
2 months ago
- Ferroptosis is a key mechanism of non-apoptotic programmed cell death in CD4+ and CD8+ T cells.
- Dietary composition, particularly polyunsaturated and monounsaturated fatty acids (PUFAs and MUFAs), influences T cell ferroptosis resistance.
- Dietary effects on ferroptosis (DEFs) are microbiota-independent and affect T cell homeostasis and immune responses.
- Human T cell ferroptosis resistance correlates with plasma lipid profiles, showing negative associations with PUFA/MUFA ratios.
- DEFs impact T cell resilience, humoral immunity, and anti-tumor immunity, including CAR-T cell therapy.
- ACSL4, which biosynthesizes PUFA-containing phospholipids, is highly expressed in T cells and regulates follicular helper T (TFH) cell function.
- Targeting lipid metabolism could enhance vaccine efficacy and T cell-mediated immunotherapy.

first prev2next

About|Login

#ferroptosis

Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunction via ALOX15-Mediated Ferroptosis - PubMed

Yitangkang decoction in the treatment of glomerular filtration barrier damage through AMPKα1/ZDHHC8/SLC7A11/GPX4 and TGF-β/Smad signaling pathways: A multi-omics analysis - PubMed

Identification of Ferroptosis-Related Hub Genes and Immune Infiltration Landscape in Chronic Kidney Disease via Bioinformatics and Experimental Verification - PubMed

Ferroptosis-autophagy crosstalk in bladder cancer: mechanisms and therapeutic implications - PubMed

Hippocampal Neuronal Ferroptosis Driven by Lipocalin-2 Mediates Comorbid Visceral Pain and Anxiety in Irritable Bowel Syndrome - PubMed

Targeting the Keap1-Nrf2/GPX4 axis to suppress ferroptosis in acute lung injury - PubMed

ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucl

Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mechanisms - PubMed

The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis - PubMed

Sodium Butyrate Alleviates IBD by Modulating SIRT1-Involved Ferroptosis and Inhibition of Macrophage Ferroptosis - PubMed

FBR-NDs: a ferroptosis-inducing nanocomplex for targeted breast cancer therapy via immune modulation and redox-responsive drug delivery - PubMed

DPP4 suppresses pancreatic cancer growth by enhancing ferroptosis sensitivity through stabilization of ACSL4 - PubMed

ALDH1L2 induces resistance to chemotherapy in small cell lung cancer by inhibiting ferroptosis - PubMed

Hyodeoxycholic acid in Arisaema Cum Bile can alleviate pentylenetetrazol-induced epilepsy by activating p53/Nrf2/GPX4 to inhibit ferroptosis - PubMed

Molecularly Engineered Phenoxazinone-Skeleton Cascade-Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis-Mediated Parkinson's Disease - PubMed

Retraction notice to "Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling" [Biomedicine & Pharmacotherapy 169 (2023) 115895] - PubMed

Acteoside targeting glutamine synthetase ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis - PubMed

STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1 - PubMed

Proteolysis-Targeting Chimeras Induce Ferroptosis in Cancer: From Mechanism to Clinical Application - PubMed

Lipid metabolism drives dietary effects on T cell ferroptosis and immunity - PubMed