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Different exercise modalities and their effects on the inflammatory mediator repertoire in breast cancer survivors: A systematic review with Bayesian network meta-analysis and dose-response analysis -
2 months ago
- The study compares effects of different exercise modalities on inflammatory mediators in breast cancer survivors.
- Exercise modalities evaluated include aerobic exercise (AE), resistance training (RT), combined exercise (CE), and low-intensity exercise (LA).
- A systematic review and network meta-analysis of 27 RCTs involving 1925 participants was conducted.
- Primary outcomes measured were IL-6, TNF-α, HSCR-P, IL-8, and IL-10 levels.
- Combined exercise (CE) was most effective in reducing IL-6, IL-8, and TNF-α.
- Aerobic exercise (AE) was most effective in reducing HSCR-P, while low-activity exercise (LA) increased IL-10.
- Subgroup analyses showed variations in biomarker responses by age and exercise dose.
- Dose-response analysis suggested optimal weekly doses for inflammation control range from 510 to 920 MET-minutes.
- Combined exercise (CE) offers the most comprehensive anti-inflammatory benefits.
- Tailoring exercise prescriptions by age and hormonal status may enhance efficacy and safety.
Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization - PubMed
2 months ago
- Study investigates associations between genetically predicted IL-6 and TNF-α signaling pathways and mortality in colorectal cancer (CRC) patients.
- Two-sample Mendelian randomization (MR) analysis used SNPs from GWAS datasets (deCODE and UK Biobank) to predict IL-6 and TNF-α signaling levels.
- Outcome data included CRC-specific mortality from 16,964 CRC cases in the GECCO consortium.
- Genetically predicted sIL6-RA showed a weak positive association with CRC-specific mortality.
- Higher IL6ST levels were associated with increased mortality in stage 2/3 CRC patients.
- No associations were found for TNF-α, sTNF-R1, or sTNF-R2 with CRC mortality.
- Simulation indicated limited collider bias for TNF-α analyses.
- Conclusions suggest IL-6 signaling may have a limited role in CRC progression, while TNF-related pathways appear less relevant for prognosis.
The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging - PubMed
2 months ago
- Phosphoenolpyruvate (PEP), a glycolytic metabolite, restricts cGAS-driven inflammation to promote healthy aging.
- Longitudinal studies in mice and humans show a biphasic PEP trajectory: initial accumulation followed by decline.
- Blocking PEP accumulation worsens inflammation and accelerates aging, while PEP administration promotes healthy aging.
- PEP competitively binds to cGAS, inhibiting the cGAS-STING pathway, reducing inflammation.
- High PEP levels in aged humans correlate with lower inflammation and healthier traits.
- PEP alleviates neuroinflammation and improves cognitive function in an Alzheimer's disease mouse model.
- PEP accumulation is identified as an evolutionarily conserved geroprotective mechanism.
Metabolic dysfunction-associated fatty liver disease and risk of knee osteoarthritis: A prospective cohort study - PubMed
2 months ago
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is linked to an 18% higher risk of knee osteoarthritis (KOA) based on a prospective cohort study.
- The study involved 303,604 participants from the UK Biobank without baseline osteoarthritis, followed for a median of 13.67 years.
- MAFLD was defined using the fatty liver index and metabolic criteria, with fibrosis severity assessed via the Fibrosis-4 score.
- Risk of KOA increased with the severity of fibrosis in MAFLD patients.
- Among MAFLD subtypes, only MAFLD-overweight/obesity showed a significant association with KOA.
- High-sensitivity C-reactive protein (hs-CRP) mediated 8.94% of the association between MAFLD and KOA, indicating a partial role of inflammation.
- The findings suggest MAFLD affects musculoskeletal health, advocating for integrated management strategies.
Association Between Inflammatory Cytokines and Systemic Inflammation Indices in Patients With Psoriasis: A Cross-Sectional Study - PubMed
2 months ago
- Study investigates the association between CBC-derived systemic inflammation indices and serum cytokines in psoriasis patients.
- 28 psoriasis patients and 23 healthy controls were included; serum cytokines and CBC-derived indices were measured.
- Psoriasis patients had higher levels of all cytokines and elevated SIRI compared to controls.
- TGF-β showed a global association with inflammation indices, but results did not remain significant after multiple testing corrections.
- SIRI and PIV showed the most consistent co-variation with cytokines, though associations were modest.
- Findings suggest the need for further validation in larger cohorts to assess CBC-derived indices as markers of inflammatory activity in psoriasis.
Obesity and Cancer: A Translational Science Review - PubMed
2 months ago
- Obesity is linked to increased risk of several cancers, including endometrial, breast, and liver cancers.
- Overweight and obesity contribute to about 10% of new cancer diagnoses annually in the US, with higher rates for certain cancers like endometrial cancer.
- Adipose tissue dysfunction in obesity leads to inflammation, altered hormone levels, and oxidative stress, promoting cancer development.
- Obesity-associated inflammation involves elevated cytokines and prostaglandins, which can stimulate tumor growth and suppress immune responses.
- Gut microbiome changes in obesity, such as reduced Akkermansia muciniphila, may further contribute to cancer risk.
- Weight loss, especially more than 10%, may reduce cancer risk by mitigating obesity-related metabolic and inflammatory effects.
Longitudinal plasma interleukin-6 and post-stroke cognitive outcomes: The Stroke-IMPaCT study - PubMed
2 months ago
- Plasma IL-6 levels measured within 96 hours of ischemic stroke and at 6-9 and 18-21 months post-stroke.
- A doubling of IL-6 between admission and 6-9 months was associated with cognitive impairment at 18-21 months (OR = 8.16).
- Each one-unit increase in IL-6 was linked to a 1.5-point decrease in memory Z-scores (β = -1.50).
- Smokers showed persistently blunted IL-6 trajectories and downregulated Toll-like receptor signaling.
- Lower socioeconomic status may relate to 6-month IL-6 concentrations via smoking.
- Post-stroke IL-6 trajectories are associated with later cognitive outcomes, suggesting potential therapeutic targets.
Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials - PubMed
2 months ago
- Creatine supplementation is widely recognized for its ergogenic effects on strength and body composition.
- Recent studies have explored its potential anti-inflammatory properties, particularly in exercise-induced stress and aging-related chronic inflammation.
- This systematic review and meta-analysis aimed to assess the effects of creatine supplementation on inflammatory biomarkers in human populations.
- Eight randomized controlled trials were included, evaluating creatine supplementation versus placebo in healthy individuals, athletes, and clinical populations.
- Primary outcomes were inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), IL-1β, TNF-α, and prostaglandin E2.
- Pooled analysis showed no significant acute effects of creatine on CRP (SMD = 0.32; 95% CI: -0.29 to 0.94; p = 0.30; I² = 28%).
- Chronic effects of creatine on CRP (SMD = -0.11; 95% CI: -0.69 to 0.48; p = 0.73; I² = 0%) and IL-6 (SMD = -0.06; 95% CI: -0.64 to 0.53; p = 0.84; I² = 0%) were also not significant.
- The certainty of evidence was rated as moderate for all outcomes.
- Creatine supplementation does not significantly reduce inflammatory biomarkers in humans based on current evidence.
- Future well-powered trials with standardized protocols are needed to clarify creatine's role in modulating inflammation.
Polypharmacy, anticholinergic burden and inflammation in relation to accelerated biological ageing - PubMed
2 months ago
- Polypharmacy and anticholinergic burden are linked to accelerated biological aging in older adults.
- Systemic inflammation partially mediates the association between polypharmacy/anticholinergic burden and biological aging.
- The study used data from the National Health and Nutrition Examination Survey (1999-2018) involving 10,556 older adults.
- 35% of participants had polypharmacy (5-9 drugs), and 5.5% had hyperpolypharmacy (10+ drugs).
- Biological aging was measured using PhenoAge, KD-BioAge, AnthroAge, frailty index, telomere length, and α-Klotho.
- Inflammation was quantified using five blood cell-based indices, with SIRI showing significant mediation effects.
- Findings emphasize the importance of deprescribing to mitigate aging-related risks.
Residual inflammatory risk as a predictor of cardiometabolic multi-morbidity: results from three prospective cohorts - PubMed
2 months ago
- Residual inflammatory risk (RIR) predicts cardiometabolic multi-morbidity (CMM) across three cohorts.
- High RIR (hsCRP >2 mg/L) was categorized into persistent high, increased, attenuated, and persistent low groups.
- Persistent high RIR significantly increased CMM risk (CHARLS: HR=2.2; HRS: HR=1.79; Panzhihua: HR=3.97).
- Association remained robust after adjusting for confounders and in subgroup analyses.
- Anti-inflammatory strategies targeting RIR reduction may mitigate CMM risk, warranting further research.
Evolving understandings for the roles of CD38 protein in autoimmunity and autoimmune disease - PubMed
2 months ago
- Autoimmune diseases are chronic idiopathic disorders characterized by inflammatory responses.
- CD38, a surface molecule with enzymatic and signaling capabilities, regulates NAD+ metabolism and mediates intracellular pathways.
- Recent research highlights CD38's role in autoimmune disease pathogenesis, influencing processes like cell recruitment, activation, and cytokine release.
- Dysfunctional CD38 can induce autoimmune diseases.
- CD38 is expressed at low levels in hematopoietic systems but elevated in multiple myeloma and plasma cells.
- CD38-targeted monoclonal antibodies (e.g., isatuximab, daratumumab, mezagitamab) show therapeutic potential in autoimmune diseases by inhibiting autoantibody production.
- CD38 is a promising biomarker for autoimmune disease diagnosis and a potential therapeutic target.
- The review focuses on CD38's involvement in autoimmunity and its research value in disease control.
A critical guideline for controlling monocyte-derived macrophages phenotypes - PubMed
2 months ago
- Macrophages (MΦ) are highly heterogeneous and adaptable innate immune cells present in all human tissues from mid-gestation.
- MΦ play roles beyond phagocytosis, including tissue homeostasis, repair, and immune regulation involving adaptive immunity.
- MΦ originate from embryonic progenitors or bone marrow, with phenotypes shaped by tissue-specific microenvironments.
- MΦ can polarize into pro-inflammatory (M1) or anti-inflammatory (M2) states, crucial for infection resolution, tissue repair, and immune balance.
- Dysregulated MΦ polarization is linked to chronic inflammation, cancer, and fibrosis.
- Tissue-resident MΦ study is limited by isolation, maintenance, and donor variability challenges.
- Monocyte-derived macrophages (MDMs) offer an easier in vitro model for human MΦ biology but differ from tissue-resident MΦ in origin and function.
- This review discusses MDM-based models, differentiation protocols, and strategies to improve reproducibility and physiological relevance in macrophage research.
Taurine supplementation as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID: a systematic review and meta-analysis - PubMed
2 months ago
- Taurine supplementation is explored as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID.
- The study is a systematic review and meta-analysis focusing on the effects of taurine on long COVID symptoms.
- Key areas of interest include cardiopulmonary function, cognition, inflammation, metabolic syndrome, and post-acute sequelae of COVID-19.
- The authors declare no competing interests, and the study does not involve human participants requiring ethics approval.
- References include studies on dysregulation of ACE2 and renin-angiotensin peptides in COVID-19 mortality and end-organ injuries.
- Other cited works discuss the role of ACE2 in the COVID-19 pandemic and urinary ACE2 in COVID-19-mediated kidney injury.
- Recent research highlights the need for translating insights into therapies for long COVID and understanding long COVID science and policy.
UVB Upregulates Inflammatory Cytokines in Rosacea Cell Model by Promoting the Expression of TRPVs and TLR2 - PubMed
2 months ago
- UVB radiation increases inflammatory cytokines in rosacea by upregulating TRPV1, TRPV4, and TLR2 expression.
- TRPV1 and TLR2 antagonists reduce IL-1β and IL-8, while TRPV4 antagonists reduce IL-6 in rosacea models.
- UVB exposure alters histone modification (H3K4me3) in the TRPV1 promoter region, suggesting epigenetic regulation.
- The study links UVB-induced inflammation in rosacea to TRPVs and TLR2, highlighting potential therapeutic targets.
Regulation of inflammatory gene transcription by ubiquitination and deubiquitination - PubMed
2 months ago
- Transcriptional responses are triggered by pathogen recognition to combat inflammatory stimuli like infections.
- Inflammatory gene transcription must be tightly regulated to avoid harmful outcomes such as immunopathology.
- The ubiquitination-deubiquitination cycle plays a key role in controlling inflammatory gene transcription via NF-κB and interferon pathways.
- Understanding gene-specific mechanisms is crucial for regulating inflammatory gene transcription.
Human and mouse long noncoding RNAs reengineered for exogenous delivery reduce LPS-induced inflammation in human macrophages and mice - PubMed
2 months ago
- Long noncoding RNAs (lncRNAs) are reengineered for exogenous delivery to treat acute inflammation.
- Three lncRNAs—GAPLINC, MIST, and DRAIR—were optimized for specificity and performance in reducing LPS-induced inflammation.
- Each lncRNA targets distinct cytokines: GAPLINC reduces IL-1β, DRAIR reduces IL-6, and MIST attenuates TNFα posttranscriptionally.
- A lipid nanoparticle delivery system was optimized for in vivo use without confounding effects.
- Reengineered GAPLINC showed potential for clinical application by reducing inflammation in human monocytes.
Efficacy, safety and mechanistic insights of pentoxifylline in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials - PubMed
2 months ago
- Pentoxifylline (PTX) shows significant improvement in HAM-D scores for major depressive disorder (MDD).
- PTX increases serotonin and BDNF levels while decreasing TNF-α and IL-6 levels.
- No significant difference in side effects between PTX and placebo groups.
- PTX may be an effective and safe adjuvant antidepressant for MDD.
- Study limitations suggest cautious interpretation of results.
Lipid accumulation product index, serum inflammatory cytokines, and dementia in rural older adults: A population-based study - PubMed
2 months ago
- The study investigates the association between the Lipid Accumulation Product (LAP) index and dementia in rural older adults in China.
- LAP index is calculated differently for men and women based on waist circumference and triglyceride levels.
- The research involved 5,670 participants, with 305 diagnosed with dementia (194 Alzheimer's disease (AD), 100 vascular dementia (VaD)).
- Higher LAP index was significantly associated with increased odds of all-cause dementia and AD, but not significantly with VaD.
- The highest quintile of LAP index showed stronger associations with dementia and AD compared to the lowest quintile.
- A significant correlation was found between higher LAP index and elevated serum inflammatory cytokines.
- The study suggests chronic systemic inflammation as a potential biological pathway linking high LAP index to dementia and AD.
Serum IL-2 levels are associated with disease activity and related to dyslipidaemia and the immunological profile in systemic lupus erythematosus - PubMed
2 months ago
- Serum IL-2 levels are linked to disease activity in systemic lupus erythematosus (SLE).
- IL-2 is associated with inflammatory markers like C-reactive protein and IL-6.
- Disease activity, measured by SLEDAI-2K, positively correlates with IL-2 levels.
- Specific autoantibodies (anti-DNA, anti-SSA, anti-SSB, anti-Sm, antiribosome) show positive associations with IL-2.
- Triglycerides are positively associated with IL-2, while HDL-cholesterol shows an inverse relationship.
- The study highlights IL-2's role in SLE immunopathogenesis, linking inflammation and metabolic pathways.
Integration of Ki67 and Pan-Immune-Inflammation Value (PIV) into a predictive nomogram for pathologic complete response in triple-negative breast cancer : (Ki67 and inflammation in triple-negative bre
2 months ago
- Study integrates Ki67 and Pan-Immune-Inflammation Value (PIV) into a predictive nomogram for pathologic complete response in triple-negative breast cancer.
- Research focuses on biomarker-based stratification, immune microenvironment, and systemic inflammation in triple-negative breast cancer.
- Retrospective study design with waived informed consent, approved by Non-Interventional Clinical Research Ethics Committee of Pamukkale University.
- Data not publicly available due to confidentiality; access possible upon request and institutional approval.
- Authors declare no competing interests.
- References include studies on prognostic significance, therapeutic vulnerabilities, and neoadjuvant chemotherapy efficacy in breast cancer.

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#inflammation

Different exercise modalities and their effects on the inflammatory mediator repertoire in breast cancer survivors: A systematic review with Bayesian network meta-analysis and dose-response analysis -

Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization - PubMed

The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging - PubMed

Metabolic dysfunction-associated fatty liver disease and risk of knee osteoarthritis: A prospective cohort study - PubMed

Association Between Inflammatory Cytokines and Systemic Inflammation Indices in Patients With Psoriasis: A Cross-Sectional Study - PubMed

Obesity and Cancer: A Translational Science Review - PubMed

Longitudinal plasma interleukin-6 and post-stroke cognitive outcomes: The Stroke-IMPaCT study - PubMed

Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials - PubMed

Polypharmacy, anticholinergic burden and inflammation in relation to accelerated biological ageing - PubMed

Residual inflammatory risk as a predictor of cardiometabolic multi-morbidity: results from three prospective cohorts - PubMed

Evolving understandings for the roles of CD38 protein in autoimmunity and autoimmune disease - PubMed

A critical guideline for controlling monocyte-derived macrophages phenotypes - PubMed

Taurine supplementation as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID: a systematic review and meta-analysis - PubMed

UVB Upregulates Inflammatory Cytokines in Rosacea Cell Model by Promoting the Expression of TRPVs and TLR2 - PubMed

Regulation of inflammatory gene transcription by ubiquitination and deubiquitination - PubMed

Human and mouse long noncoding RNAs reengineered for exogenous delivery reduce LPS-induced inflammation in human macrophages and mice - PubMed

Efficacy, safety and mechanistic insights of pentoxifylline in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials - PubMed

Lipid accumulation product index, serum inflammatory cytokines, and dementia in rural older adults: A population-based study - PubMed

Serum IL-2 levels are associated with disease activity and related to dyslipidaemia and the immunological profile in systemic lupus erythematosus - PubMed

Integration of Ki67 and Pan-Immune-Inflammation Value (PIV) into a predictive nomogram for pathologic complete response in triple-negative breast cancer : (Ki67 and inflammation in triple-negative bre