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Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis - PubMed
a month ago
- 7-Dehydrocholesterol (7-DHC) acts as an endogenous suppressor of ferroptosis.
- The study involves multiple authors and institutions, highlighting collaborative research.
- Published in Nature, the article provides insights into the molecular mechanisms of ferroptosis suppression.
- The findings could have implications for understanding cell death mechanisms and potential therapeutic targets.
Macrophage-derived legumain ameliorates excessive mechanical stress-induced ferroptosis of nucleus pulposus cells and intervertebral disc degeneration via integrin αvβ3-Hippo signaling - PubMed
a month ago
- Macrophage-derived legumain helps reduce ferroptosis in nucleus pulposus cells caused by excessive mechanical stress.
- The study identifies integrin αvβ3-Hippo signaling as a key pathway in mitigating intervertebral disc degeneration.
- Ethical approvals were obtained from Southeast University and Zhongda Hospital for both animal and human studies.
- The authors declare no competing interests.
- References highlight the global burden of low back pain and its association with intervertebral disc degeneration.
- Funding sources include the National Natural Science Foundation of China and other institutional grants.
The tRNA-Derived Fragment tRF-E Promotes Ferroptosis in Hepatocellular Carcinoma to Suppress Tumor Progression - PubMed
a month ago
- tRF-E, a tRNA-derived fragment, acts as a tumor suppressor in hepatocellular carcinoma (HCC).
- Low levels of tRF-E are associated with poor prognosis in HCC patients across multiple cohorts.
- tRF-E promotes ferroptosis in HCC cells both in vitro and in vivo, suppressing tumor progression.
- Mechanistically, tRF-E stabilizes VDAC2 by blocking its Nedd4-mediated ubiquitination, enhancing iron-dependent lipid peroxidation.
- SRSF6 generates tRF-E by cleaving tRNAGluTTC, but hypoxia inhibits this process by suppressing SRSF6 via alternative splicing and nonsense-mediated mRNA decay.
ALDH2 Mediated Ferroptosis Regulation in Ischemia-Reperfusion Injury - PubMed
a month ago
- ALDH2 is an important protective enzyme against ischemia-reperfusion injury (IRI).
- Ferroptosis is a key cell death pathway in IRI driven by iron and lipid peroxidation.
- ALDH2 and ferroptosis intersect, with ALDH2 limiting toxic lipid peroxidation products.
- Targeting ALDH2 may be a strategy to reduce ferroptosis and tissue damage in IRI.
Lipid metabolic reprogramming of CD8+ T cells in the tumor microenvironment - PubMed
a month ago
- Lipid metabolic reprogramming in the tumor microenvironment contributes to CD8+ T cell dysfunction and limits cancer immunotherapy efficacy.
- Hypoxia, acidosis, obesity, and hyperlipidemia collectively impose a metabolic siege on CD8+ T cells.
- Dysregulated lipid pathways include CD36-mediated uptake of oxidized lipids, which promotes ferroptosis.
- Cholesterol homeostasis disruption impairs TCR signaling and triggers endoplasmic reticulum stress via the IRE1α-XBP1 axis, leading to immune checkpoint expression.
- Therapeutic strategies involve modulating lipid transporters and metabolic engineering of CAR-T cells to restore T cell function.
Cysteine imaging reveals early redox dysregulation and identifies gnetol as a ferroptosis-modulating agent in doxorubicin cardiotoxicity - PubMed
a month ago
- Doxorubicin (DOX) causes cardiotoxicity with cysteine depletion as an early redox event, preceding systolic dysfunction.
- A cardiotoxicity-responsive cysteine probe (CCP) enabled in vivo imaging and identified cysteine loss three weeks after DOX treatment, linked to glutathione depletion, iron accumulation, and ferroptosis.
- Screening with the probe led to discovery of gnetol, a polyphenolic stilbene, which restored cysteine and glutathione, reduced lipid peroxidation, and suppressed ferroptosis via the SMAD-hepcidin-FPN1 axis and GPX4 activity.
- In a mouse model of DOX-induced cardiomyopathy, gnetol improved cardiac function, reduced myocardial injury and fibrosis, and lowered oxidative stress without systemic toxicity.
- Cysteine-targeted redox imaging facilitates mechanism-guided discovery of cardioprotective agents, positioning gnetol as a promising ferroptosis inhibitor for early intervention in redox-driven cardiac injury.
Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma via chaperone-mediated autophagy-dependent GPX4 degradation - PubMed
a month ago
- Ginkgolic acid (GAC), from Ginkgo biloba, inhibits hepatocellular carcinoma (HCC) cell viability by inducing ferroptosis.
- GAC directly targets HSPA8, enhancing its interaction with glutathione peroxidase 4 (GPX4).
- This interaction leads to CMA-dependent degradation of GPX4, reducing glutathione levels and causing lipid peroxidation.
- In vivo studies show GAC suppresses tumor growth in an orthotopic HCC model, increasing lipid peroxidation and GPX4 degradation.
- The findings suggest GAC-mediated ferroptosis as a potential therapeutic strategy against HCC, expanding applications for CMA-targeted therapies.
The phospholipid profile of T cells shapes ACSL4 dependency and ferroptosis sensitivity of naive, effector, and memory T cells - PubMed
a month ago
- The study identifies ACSL4 as the main ferroptosis inducer in primary T cells in vitro, with other iron- and lipid metabolism-related genes having minor effects.
- Phospholipid (PL) composition, specifically the presence of polyunsaturated fatty acid-containing PLs (PUFA-PLs), determines ACSL4 dependency and ferroptosis susceptibility; effector CD8+ T cells, rich in PUFA-PLs, undergo ferroptosis without ACSL4.
- Naive and memory T cells share a similar PL profile low in PUFA-PLs, making them resistant to ferroptosis, highlighting PLs as a key factor in differential ferroptosis sensitivity among T cell subsets.
A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linking Ferroptosis to Mitochondrial Dysfunction in Epilepsy - PubMed
a month ago
- The study integrates snRNA-seq and bulk RNA-seq data to explore cell-specific roles in epilepsy, focusing on ferroptosis and mitochondrial dysfunction.
- Six key microglial genes (ATM, TGFBR1, ZEB1, PARP14, GJA1, ALOX5) are identified, linking ferroptosis and mitochondrial dysfunction in epilepsy.
- Analyses reveal associations with immune infiltration, such as increased Th1 cells and reduced CD8+ T cells, and enrichment in neuroinflammatory pathways and interferon response.
- PARP14 is upregulated in epileptic rats and identified as a novel factor in epileptogenesis, while GJA1 shows stable binding with bleomycin, suggesting therapeutic potential.
- In vivo validation confirms ferroptosis and mitochondrial damage in epilepsy, highlighting these processes as targets for future mechanistic and therapeutic research.
Extracellular GPX4 functions as an immunosuppressive DAMP in ferroptosis - PubMed
a month ago
- Extracellular GPX4 acts as an immunosuppressive damage-associated molecular pattern (DAMP) during ferroptosis.
- It impairs antitumor immunity by interacting with dendritic ZP3 receptors.
- The authors declare no competing interests, and the findings are linked to a specific study on this mechanism in cancer immunity.
Malic enzyme 1 contributes to tumorigenesis and lenvatinib resistance in hepatocellular carcinoma via FSP1-dependent ferroptosis evasion - PubMed
a month ago
- ME1 is significantly upregulated in hepatocellular carcinoma (HCC) tissues and linked to poor prognosis.
- ME1 promotes HCC cell viability in vitro and tumor growth in vivo, with knockout reducing tumor burden in mice.
- ME1 overexpression confers resistance to lenvatinib, a first-line HCC drug, while ME1 knockout restores sensitivity.
- ME1 regulates ferroptosis in HCC cells through NADPH production, activating the NADPH-FSP1-CoQH2 axis.
- FSP1 uses ubiquinol (CoQH2) as an antioxidant to inhibit lipid peroxide accumulation and prevent ferroptosis.

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#ferroptosis

Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis - PubMed

Macrophage-derived legumain ameliorates excessive mechanical stress-induced ferroptosis of nucleus pulposus cells and intervertebral disc degeneration via integrin αvβ3-Hippo signaling - PubMed

The tRNA-Derived Fragment tRF-E Promotes Ferroptosis in Hepatocellular Carcinoma to Suppress Tumor Progression - PubMed

ALDH2 Mediated Ferroptosis Regulation in Ischemia-Reperfusion Injury - PubMed

Lipid metabolic reprogramming of CD8+ T cells in the tumor microenvironment - PubMed

Cysteine imaging reveals early redox dysregulation and identifies gnetol as a ferroptosis-modulating agent in doxorubicin cardiotoxicity - PubMed

Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma via chaperone-mediated autophagy-dependent GPX4 degradation - PubMed

The phospholipid profile of T cells shapes ACSL4 dependency and ferroptosis sensitivity of naive, effector, and memory T cells - PubMed

A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linking Ferroptosis to Mitochondrial Dysfunction in Epilepsy - PubMed

Extracellular GPX4 functions as an immunosuppressive DAMP in ferroptosis - PubMed

Malic enzyme 1 contributes to tumorigenesis and lenvatinib resistance in hepatocellular carcinoma via FSP1-dependent ferroptosis evasion - PubMed